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By rearing zebrafish in a "bubble" devoid of
all microbes, Karen Guillemin has shown that
the bacteria in the gut play crucial roles in
normal development. Using molecular, genetic, and
genomic approaches, her lab has discovered that
bacteria use a wealth of different signaling strategies
to communicate with their hosts and promote normal
development or disease.
"We're running up against questions that require new approaches.
The need to integrate ideas from many different disciplines keeps
us on an incredible learning curve."